Mutant DNase1L3 with improved serum half-life
Grant
US12577571B2
Kind: B2
Mar 17, 2026
Assignee
Texas Tech University System
Inventors
Peter Keyel, Roger B. Sutton, Jon McCord
Abstract
The present invention includes a mutant Dnase1LS having at least about a 95% identity with a nucleic acid sequence encoding the protein of SEQ ID NO: 2-8 for a mutant Dnase1LS comprising at least one mutation for post-translational modification or attachment of a molecule to the mutant Dnase1LS to increase the serum half-life of the mutant Dnase1LS, nucleic acids encoding the same, host cells, and methods of making the mutant Dnase1LS.
CPC Classifications
C12Y 301/21001
C12N 9/16
C12N 15/70
C12N 15/52
C12N 15/815
Filing Date
2020-10-01
Application No.
17763913
Claims
13