Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use
Grant
US12577565B2
Kind: B2
Mar 17, 2026
Assignee
SUZHOU RIBO LIFE SCIENCE CO., LTD.
Inventors
Hongyan Zhang, Shan Gao, Daiwu Kang
Abstract
An siRNA inhibiting xanthine oxidase (XO) gene expression, a pharmaceutical composition containing the siRNA, a siRNA conjugate, and an application of the siRNA in the preparation of drugs for treating and/or preventing uric acid metabolism disorder or diseases or physical conditions caused by uric acid metabolism disorder. Each nucleotide in the siRNA is an independent modified or unmodified nucleotide, and the siRNA contains a sense strand and an antisense strand.
CPC Classifications
C12N 15/113
C12N 2310/14
Filing Date
2020-05-21
Application No.
17595594
Claims
20