PDCD-1 homing endonuclease variants
Grant
US12577547B2
Kind: B2
Mar 17, 2026
Assignee
REGENERON PHARMACEUTICALS, INC.
Inventors
Jordan Jarjour, Kyle Havens, Jasdeep Mann
Abstract
The present disclosure provides improved homing endonuclease variants and megaTALs reprogrammed to bind and cleave the PDCD-1 gene.
CPC Classifications
C12N 9/22
C12N 15/85
C12N 15/907
A61K 35/17
Filing Date
2019-12-09
Application No.
17311455
Claims
18