Cells for enhanced production of adeno-associated virus
Grant
US12577539B2
Kind: B2
Mar 17, 2026
Assignee
The Regents of the University of California
Inventors
David V. Schaffer, Christopher Barnes, David Stephen Ojala
Abstract
The present disclosure provides an in vitro mammalian cell that is genetically modified to provide for enhanced production of adeno-associated virus (AAV) virions. The mammalian cells can be used to produce AAV virions, e.g., recombinant AAV virions that include a heterologous nucleic acid encoding a gene product; the present disclosure thus provides methods for producing an AAV virion, which may be a recombinant AAV virion.
CPC Classifications
C12N 7/00
C12N 15/1058
C12N 15/11
C12N 15/63
C12N 15/85
C12N 15/86
C12N 2310/20
C12N 2310/02
C12N 2750/14152
C12N 2800/107
Filing Date
2020-04-22
Application No.
17605387
Claims
10