Antibody-mediated transduction of heat shock proteins into living cells
Grant
US12577294B2
Kind: B2
Mar 17, 2026
Assignee
THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Inventors
Richard H. Weisbart, Robert N. Nishimura, James E. Hansen
Abstract
The invention provides for a fusion protein comprising a 3E10 Fv joined to a Hsp-70, Hsp-27, Hsp-90 or GRP-78 or portion thereof, and optionally, the 3E10 Fv comprising an amino acid sequence AGIH at its amino terminus.
CPC Classifications
C07K 16/18
C07K 14/47
C07K 2317/56
C07K 2317/622
C07K 2317/77
C07K 2319/33
A61K 38/00
Filing Date
2020-05-27
Application No.
16884942
Claims
14