T cell receptors which recognize mutated EGFR
Grant
US12577286B2
Kind: B2
Mar 17, 2026
Assignee
The United States of America, as represented by the Secretary, Department of Health and Human Services
Inventors
Kenichi Hanada, Chihao Zhao, Anna Pasetto, James C. Yang
Abstract
Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated EGFR amino acid sequence with a E746-A750 deletion. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
CPC Classifications
A61K 35/17
Filing Date
2019-05-01
Application No.
17051860
Claims
29