Antagonists of the muscarinic acetylcholine receptor M4
Grant
US12577234B2
Kind: B2
Mar 17, 2026
Assignee
Vanderbilt University
Inventors
Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Julie L. Engers, Kayla J. Temple, Aaron M. Bender, Logan A. Baker
Abstract
Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
CPC Classifications
C07D 403/14
C07D 209/52
C07D 401/14
C07D 403/12
C07D 405/14
C07D 413/14
C07D 417/12
C07D 471/04
C07D 493/08
Filing Date
2023-10-13
Application No.
18486712
Claims
20