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Dihydrocyclopenta-isoquinoline-sulfonamide derivatives compounds

Grant US12577228B2 Kind: B2 Mar 17, 2026

Assignee

UCB Biopharma SRL

Inventors

Timothy John Norman, Douglas Byrne, Julian Hugh Rowley, Giancarlo Trani, Konstantinos Rampalakos, Nathaniel Julius Thomas Monck, Benedicte Lallemand, Gregory William Haslett, Rickki Lee Connelly, Jag Paul Heer, James Madden, Oliver Philps, Selvaratnam Suganthan, Zeshan Yousuf, Richard John Mears

Abstract

The present invention relates to dihydrocyclopenta-isoquinoline-sulfonamide derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use in treating disorders caused by IgE (such as allergic responses, non-allergic mast cell responses or certain autoimmune responses), and in particular disorders caused by the interaction of IgE with the FcεRI receptor.

CPC Classifications

C07D 401/14 C07D 221/06

Filing Date

2020-12-22

Application No.

17786394

Claims

18