Nuclear transport modulators and uses thereof
Grant
US12577225B2
Kind: B2
Mar 17, 2026
Assignee
Karyopharm Therapeutics Inc.
Inventors
Erkan Baloglu, Sharon Shacham, Dilara McCauley, Trinayan Kashyap, William Senapedis, Yosef Landesman, Gali Golan, Ori Kalid, Sharon Shechter
Abstract
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.
CPC Classifications
A61K 31/506
A61K 31/501
A61K 31/4196
A61K 31/422
A61K 31/426
A61K 31/4439
A61K 31/4709
C07D 249/08
C07D 401/06
C07D 403/06
C07D 413/06
C07D 417/06
A61P 35/00
A61P 31/12
A61P 29/00
A61P 27/02
A61P 25/28
A61P 25/00
A61P 17/02
A61P 11/00
A61P 3/04
Filing Date
2024-02-23
Application No.
18586019
Claims
17