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Phenethylamine compounds salts, polymorphic forms and methods of use thereof

Grant US12577222B2 Kind: B2 Mar 17, 2026

Assignee

Terran Biosciences Inc.

Inventors

Samuel Clark

Abstract

Disclosed herein are salts and solid forms of MDMA, (R)-MDMA, (S)-MDMA, MDE, S-MDE, R-MDE, MDAI, MBDB, S-MBDB, R-MBDB, MEAI, and 5,6-Dimethoxy-2-aminoindane, including salts, solid forms of the compound and salts thereof, as well as polymorphs of solid forms. The solid forms disclosed herein may have improved properties, such as improved physical, chemical, and/or pharmacokinetic properties. Also disclosed are methods for making the salts and solid forms and methods for administering the same. The disclosed salt and solid forms of MDMA, (R)-MDMA, (S)-MDMA, MDE, S-MDE, R-MDE, MDAI, MBDB, S-MBDB, R-MBDB, MEAI, and 5,6-Dimethoxy-2-aminoindane may be useful for treating neurological disease and/or a psychiatric disorder in a subject.

CPC Classifications

C07C 217/74 C07C 2602/08 C07C 57/15 C07D 317/58 C07D 317/70 A61K 45/06 A61P 25/22 C07B 2200/13

Filing Date

2024-01-19

Application No.

18418122

Claims

38