Pyrazolone formyl peptide 2 receptor agonists
Grant
US12577206B2
Kind: B2
Mar 17, 2026
Assignee
Bristol-Myers Squibb Company
Inventors
James A. Johnson, Zulan Pi, Nicholas R. Wurtz, Joanne M. Smallheer, Meriah Neissel Valente, Ellen K. Kick, Charles G. Clark, Pravin Sudhakar Shirude, Balaji Seshadri, Amit Kumar Chattopadhyay
Abstract
The disclosure relates to compounds of formula I, which are formyl peptide 2 (FPR2) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
CPC Classifications
C07D 231/50
C07D 401/04
C07D 401/14
C07D 405/14
C07D 413/14
C07D 451/02
C07D 403/04
C07D 407/14
C07D 413/06
C07D 487/08
C07D 491/10
C07D 231/44
A61P 9/00
A61P 11/00
Filing Date
2021-07-08
Application No.
18004722
Claims
27