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Bispecific nanoparticle systems for targeting cancer cells

Grant US12576160B2 Kind: B2 Mar 17, 2026

Assignee

University of Notre Dame du Lac

Inventors

Prakash Daniel Nallathamby

Abstract

Described herein are compositions and methods for targeting cancer cells and inducing cell death. In one embodiment, the composition comprises a nanoparticle system comprising a plurality of antibodies that recognize CAR-T cells and a plurality of antibodies that recognize cancer cells. The composition targets CAR-T cells to the vicinity of cancer cells, whereby upon activation, the CAR-T cells can effectuate cancer cell death.

CPC Classifications

A61K 47/6929

Filing Date

2022-05-06

Application No.

18547664

Claims

12