CD4+ T cells expressing IL-10 and chimeric antigen receptors and uses thereof

Abstract

The present disclosure provides a population of CD4IL-10/CAR cells (autologous or allogeneic single-donor and allogeneic polydonor) generated by genetically modifying CD4+ T cells to express IL-10 and a chimeric antigen receptor. Further provided are methods of generating the CD4IL-10/CAR cells and methods of using the CD4IL-10/CAR cells for immune tolerization, treating GvHD, cell and organ transplantation, cancer, and other autoimmune and inflammatory disorders.

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