Recombinant proteins with CD40 activating properties
Grant
US12576147B2
Kind: B2
Mar 17, 2026
Assignee
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
Inventors
Yves Levy, Valentina Ceglia, Sandra Zurawski, Gerard Zurawski
Abstract
CD40 activating proteins comprising recombinant proteins with CD40 agonist antibodies or their antigen-binding fragments fused or linked to CD40 ligand are provided. The CD40 activating proteins may further comprise at least one antigen. Uses for the CD40 activating proteins include inducing immune responses directed to delivered antigens such as viral or cancer antigens. Properties of the CD40 activating protein may include the ability to induce proliferation of B cells or secretion of cytokines, such as IL-6, IL-12 and/or IL-15.
CPC Classifications
A61K 39/39541
A61K 39/385
A61K 2039/505
A61K 2039/6056
A61P 31/18
C07K 14/70575
C07K 16/2878
Filing Date
2020-03-26
Application No.
17598582
Claims
17