Compounds and methods for the immobilization of myostatin-inhibitors on the extracellular matrix by transglutaminase
Grant
US12576138B2
Kind: B2
Mar 17, 2026
Assignee
Julius-Maximilians-Universität Würzburg
Inventors
Lorenz Meinel, Tessa Lühmann, Alexandra Braun
Abstract
The present invention relates to compounds and their use in the treatment of lesions, in tissue regeneration and/or tissue engineering. The compounds act as substrates for enzymes having transglutaminase activity and are suitable for their immobilization and/or attached therapeutic or diagnostic molecules on extracellular matrix (ECM) or synthetic ECM-derived materials, in particular for the immobilization of myostatin inhibitors.
CPC Classifications
A61K 38/45
A61K 9/0014
A61K 9/0024
A61K 9/06
A61K 38/10
A61K 38/30
A61K 39/3955
A61K 47/65
A61K 38/00
A61L 15/40
A61L 15/60
A61L 27/225
A61L 27/227
A61L 27/24
A61L 27/3633
A61L 27/365
A61L 27/507
A61L 27/54
A61L 27/56
A61L 31/047
A61L 31/16
A61P 17/02
C12N 9/1044
C12Y 203/02013
C07K 2319/01
C07K 2319/70
C07K 14/65
C07K 14/475
Filing Date
2019-05-17
Application No.
17047851
Claims
11