Altering inflammatory states of immune cells in vivo by modulating cellular activation states
Grant
US12576131B2
Kind: B2
Mar 17, 2026
Assignee
Fred Hutchinson Cancer Center
Inventors
Matthias Stephan
Abstract
Systems and methods to modulate the activation state of immune cells in vivo are described. The systems and methods can be used to transform immunosuppressive macrophages that support cancer growth and metastasis into highly activated tumoricidal macrophages.
CPC Classifications
A61K 9/146
A61K 38/45
A61K 9/5153
A61K 47/54
A61K 99/0024
C12N 15/11
A61P 35/00
Filing Date
2019-01-18
Application No.
16963119
Claims
14