Dominant negative SARM1 molecules comprising a substitution at position 189, 190, 193, 194, 570 and/or 685 of SARM1
Grant
US12576130B2
Kind: B2
Mar 17, 2026
Assignee
Washington University
Inventors
Aaron DiAntonio, Jeffrey D. Milbrandt, Daniel Summers, Stefanie Geisler, Xianrong Mao
Abstract
The present invention provides compositions useful as inhibitors of SARM1 activity, pharmaceutical compositions thereof, and methods of using the same. The present invention provides dominant negative SARM1 molecules useful for treating a neurodegenerative or neurological disease or disorder, pharmaceutical compositions thereof, and methods of using the same.
CPC Classifications
A61K 38/00
A61K 38/1709
A61K 38/1761
A61K 38/16
A61K 47/6815
C07K 14/47
C07K 14/00
C07K 14/4702
C07K 14/4747
A61P 25/00
A61P 25/28
A61P 21/00
Filing Date
2018-10-18
Application No.
16757254
Claims
9