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Combination therapy for cancer

Grant US12576122B2 Kind: B2 Mar 17, 2026

Assignee

UNITED ARAB EMIRATES UNIVERSITY

Inventors

Amr Amin

Abstract

Methods of treating, suppressing, or reducing the severity of a liver cancer in a subject are described herein. The disclosed methods include administering to the subject a first amount of safranal or a pharmaceutically acceptable pro-drug thereof and administering to the subject a second amount of a TOP1 inhibitor. In some embodiments, the TOP1 inhibitor is irinotecan, topotecan, camptothecin, lamellarin D, and/or combinations thereof.

CPC Classifications

A61K 31/4745 A61K 31/11 A61K 31/44 A61K 36/88 A61P 35/00

Filing Date

2019-02-11

Application No.

16272515

Claims

3