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Oral brexanolone compositions and methods of preparation and use

Grant US12576090B1 Kind: B1 Mar 17, 2026

Inventors

Nachiappan Chidambaram, Mahesh V. Patel, Jonathan Ogle, Kongnara Papangkorn, Samuel Akapo, Joel Frank, Benjamin J. Bruno

Abstract

Disclosed is a method and a brexanolone containing oral composition for treating CNS disorders such as depression. An embodiment of the invention comprises orally administering a brexanolone containing composition to a subject having a CNS disorder. The composition and methods disclosed herein exhibit effective oral absorption/bioavailability and a predetermined ratio of bioavailability in a fed state administration relative to a fasted state administration.

CPC Classifications

A61K 31/57 A61P 25/24

Filing Date

2024-11-18

Application No.

18950383

Claims

30