Methods for enhancing cytotoxic cancer therapy through inhibition of ATG4B
Grant
US12576088B2
Kind: B2
Mar 17, 2026
Assignee
Northwestern University
Inventors
Shi-Yuan Cheng, Bo Hu, Tianzhi Huang
Abstract
Disclosed are methods and compositions for treating cell proliferative diseases and disorders such as cancers. Particularly disclosed are methods and composition for treating cancers such as glioblastoma by administering a therapeutic agent that inhibits the biological activity of the autophagy related 4B cysteine peptidase (ATG4B) protein in conjunction with additional therapeutic agents or treatments.
CPC Classifications
A61K 31/4402
A61P 35/00
Filing Date
2023-09-15
Application No.
18468453
Claims
10