Aryloxypiperidine pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors
Grant
US12576087B2
Kind: B2
Mar 17, 2026
Assignee
Merck Sharp & Dohme LLC
Inventors
Dane Clausen, Xavier Fradera, Liangqin Guo, Yongxin Han, Shuwen He, Xianhai Huang, Joseph Kozlowski, Guoqing Li, Jongwon Lim, Theodore A. Martinot, Alexander Pasternak, Nunzio Sciammetta, Andreas Verras, Li Xiao, Wensheng Yu, Rui Zhang
Abstract
Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
CPC Classifications
A61K 31/5377
A61K 31/454
A61K 31/4545
A61K 31/46
A61K 31/496
A61K 45/06
C07D 401/06
C07D 401/14
C07D 413/14
C07D 451/06
A61P 25/24
A61P 25/28
A61P 27/12
A61P 31/12
A61P 35/00
A61P 37/00
Filing Date
2019-08-16
Application No.
17268995
Claims
13