USE OF A SMALL NATIVE PEPTIDE ACTIVATOR OF SERCA PUMP FOR TREATMENT OF HEART FAILURE AND OTHER DISORDERS CHARACTERIZED BY CYTOSOLIC CALCIUM OVERLOAD
Application
US20260098067A1
Kind: A1
Apr 09, 2026
Assignee
The Board of Regents of The University of Texas System
Inventors
Eric N. OLSON, Rhonda S. BASSEL-DUBY, Catherine A. MAKAREWICH, Benjamin R. NELSON
Abstract
The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.
CPC Classifications
C07K 14/47
A61K 38/1709
A61K 45/06
A61K 48/0058
Filing Date
2025-06-05
Application No.
19229899