METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
Application
US20260098032A1
Kind: A1
Apr 09, 2026
Inventors
Binh VU, Romyr DOMINIQUE, Hongju LI, Bruce FAHR, Andrew GOOD
Abstract
Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
CPC Classifications
C07D 405/14
C07D 209/14
C07D 401/12
C07D 401/14
C07D 403/06
C07D 403/12
C07D 405/12
C07D 409/12
C07D 409/14
C07D 417/14
C07D 471/04
C07D 471/08
C07D 491/107
C07F 7/0812
C07H 15/26
Filing Date
2025-05-15
Application No.
19209328