KIF18A INHIBITORS
Application
US20260098029A1
Kind: A1
Apr 09, 2026
Assignee
AMGEN INC.
Inventors
Nuria A. TAMAYO, Abhisek BANERJEE, James Alexander BROWN, Michael J. FROHN, Jian Jeffrey CHEN, Kexue LI, Qingyian LIU, Jonathan Dante LOW, Vu MA, Liping H. PETTUS, Mary Catherine WALTON, Ana Elena MINATTI, Matthew Paul BOURBEAU, Lei JIA
Abstract
Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.
CPC Classifications
C07D 401/14
C07D 401/12
C07D 405/14
C07D 413/14
C07D 419/14
C07D 491/107
Filing Date
2025-10-15
Application No.
19359179