M4 ACTIVATORS/MODULATORS AND USES THEREOF
Application
US20260098026A1
Kind: A1
Apr 09, 2026
Inventors
Hanh Nguyen, Shea Johnson, Xiaofeng Zhang, Sokhom Pin, Jongwon Lim, Hongjun Zhang
Abstract
The present disclosure provides compounds of Formula I: (I), or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: A, Y, m, n, p, R1, R2, R3, R3a, R4, R5, R6, R7, and Z are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, Parkinson's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.
CPC Classifications
C07D 401/14
A61K 31/4545
A61K 31/496
A61K 31/497
A61K 31/4995
A61K 31/501
A61K 31/506
A61K 31/513
A61K 31/519
A61K 31/5365
A61K 31/5377
A61K 31/538
A61K 31/695
C07B 59/002
C07D 405/14
C07D 409/14
C07D 413/14
C07D 417/14
C07D 471/04
C07D 487/04
C07D 487/08
C07D 491/107
C07D 495/10
C07D 498/04
C07F 7/0812
C07B 2200/05
Filing Date
2023-09-15
Application No.
19112200