DIMERIC COMPOUNDS AS INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF
Application
US20260098025A1
Kind: A1
Apr 09, 2026
Inventors
David John MORGANS, JR., Kevin MELLEM, Patrick Sang Tae LEE, Christopher Joseph SINZ, Alexander Wayne SCHAMMEL, Chris ZIEBENHAUS, Jessica WAHLERS, Christos TZITZILONIS, Nathan FASTMAN
Abstract
Provided herein are compounds of formula (I): (G1-Z1)-L-(G2-Z2), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein G1, G2, Z1, Z2, and L, are as defined elsewhere herein. Also provided herein are methods of preparing compounds of formula (I). Also provided herein are methods of inhibiting GYS1 and methods of treating a GYS1-mediated disease, disorder, or condition in an individual in need thereof.
CPC Classifications
C07D 401/14
A61K 31/444
A61K 31/513
A61K 38/47
A61K 47/55
C07D 213/61
C12Y 302/0102
Filing Date
2023-09-13
Application No.
19111739