BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF
Inventors
Bradley P. MORGAN, Chris EVANS, Pu-Ping LU, Makoto YAMASAKI, Wenyue WANG, Scott COLLIBEE, Takuya MAKINO, Kazuyuki TSUCHIYA, Toshio KUROSAKI, Susumu YAMAKI, Eriko HONJO, Yuka KOIZUMI, Naoto KATOH, Ryuichi SEKIOKA, Ikumi KURIWAKI
Abstract
Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.
CPC Classifications
Filing Date
2025-07-07
Application No.
19261878