SYSTEMS AND METHODS OF SAFE MODEL-BASED MULTIVARIABLE CONTROL OF PERITONEAL PERFUSION

Abstract

In accordance with the present disclosure, a method for automatically controlled peritoneal perfusion includes receiving perfusion parameters such as a predefined intra-abdominal volume and inflow rate and circulating a perfusate between a reservoir and a subject's cavity using an inflow pump and an outflow pump. A reservoir volume may be measured by a weight sensor, inflow data may be obtained from a flow-rate sensor and a commanded flow rate may be accessed from the outflow pump. A drainage efficiency of the outflow pump may then be estimated using the reservoir volume, inflow rate, and the commanded outflow rate. A drainage efficiency model may be identified from experimental or operational data to represent efficiency dynamics. Based on this model, a perfusion safety control routine may evaluate a safety barrier function and adjust operation of the inflow and outflow pumps to maintain safety and compliance with the perfusion parameters.

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