4-1BBL AND IL-12 THERAPY FOR TREATMENT OF GLIOBLASTOMA
Application
US20260097096A1
Kind: A1
Apr 09, 2026
Inventors
Koen Breyne, Xandra O. Breakefield, Thorsten R. Mempel
Abstract
Provided herein are methods of treating glioblastoma including administering to a subject having glioblastoma a therapeutically effective amount of a pharmaceutical composition comprising 4-1BBL, optionally in combination with recombinant IL-12. The 4-1BBL can be provided to the subject via an adeno-associated virus, for example AAV-F, and the IL-12 can be provided by intratumoral injection.
CPC Classifications
A61K 38/177
A61K 38/208
A61K 48/005
A61P 35/00
C12N 15/86
C12N 2740/15043
C12N 2750/14143
Filing Date
2023-09-27
Application No.
19115409