RECOMBINANT FUSION POLYPEPTIDES FOR SECRETING SOLUBLE, HETEROLOGOUS CARGO
Application
US20260097087A1
Kind: A1
Apr 09, 2026
Inventors
Weston R. Whitaker, William C. DeLoache, Zachary N. Russ, Lauren Popov, Ada Huang, David Zong, Jake Flood, John Dueber
Abstract
Methods and compositions comprising recombinant fusion polypeptides that are engineered to allow for heterologous cargo secretion from a Bacteroides cell, into an extracellular environment are provided. Provided methods and compositions include recombinant fusion polypeptides comprising a secretion domain and a heterologous cargo domain. Methods and compositions for using said recombinant fusion polypeptides, e.g., for the treatment of a disease and/or disorder, are also provided.
CPC Classifications
A61K 35/741
A61K 31/737
C12N 1/20
C12N 9/0069
C12N 15/62
C12P 21/02
G01N 33/6872
C07K 2319/036
C07K 2319/40
C07K 2319/50
C07K 2319/61
C12Y 113/12005
Filing Date
2023-09-22
Application No.
19114043