CHIMERIC ANTIGEN RECEPTORS SPECIFIC TO B-CELL MATURE ANTIGEN (BCMA) AND/OR TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR (TACI)
Application
US20260097076A1
Kind: A1
Apr 09, 2026
Inventors
Yan CHEN, Garima AGRAHARI, Kehao ZHAO, Jenna NGUYEN, Keming ZHANG, Ning JIANG, Katie O'CALLAGHAN
Abstract
Genetically engineered immune cells (e.g., T cells or NK cells) expressing anti-BCMA, anti-TACI, or anti-BCMA/anti-TACI chimeric antigen receptors and uses thereof in cancer therapy. In some embodiments, the genetically engineered immune cells may be armored CAR-T or CAR-NK cells, which further express an armor polypeptide for enhancing CAR-T or CAR-NK cell features.
CPC Classifications
A61K 35/17
A61K 40/11
A61K 40/15
A61K 40/31
A61K 40/4215
A61P 35/00
C07K 14/7051
C07K 14/70521
C07K 14/70575
C07K 14/70578
C07K 16/2878
C12N 15/86
A61K 2239/13
A61K 2239/17
A61K 2239/21
A61K 2239/29
C07K 2317/565
C07K 2317/622
C07K 2319/02
C12N 2740/15043
Filing Date
2023-09-20
Application No.
19112720