COMPOSITIONS OF ADAGRASIB AND mTOR INHIBITORS AND METHODS OF TREATMENT THEREWITH
Application
US20260097038A1
Kind: A1
Apr 09, 2026
Assignee
MIRATI THERAPEUTICS, INC.
Inventors
Peter Olson, Ruth Wei Aranda, James Gail Christensen, Lars Daniel Engstrom, Jill Hallin
Abstract
The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a mTOR inhibitor and a KRas G12C inhibitor of Formula (I), Formula I-A or Formula I-B, pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.
CPC Classifications
A61K 31/519
A61K 31/436
A61K 31/4745
A61K 31/5377
A61P 35/00
Filing Date
2025-12-02
Application No.
19406155