COMPOSITIONS COMPRISING MODIFIED, TRUNCATED GLCNAC-1-PHOSPHOTRANSFERASE

Abstract

Provided are amino acid sequences for modified, truncated forms of human GlcNA-1-Phosphotransferase (PTase) that retain phosphotransferase activity and the ability to phosphorylate proteins, lysosomal or non-lysosomal. Truncated forms of PTase lacking or with modified linkers and/or lacking the C-terminal transmembrane and cytosolic domain are demonstrated to retain phosphotransferase activity and the ability to phosphorylate target proteins.

CPC Classifications