PEPMIXES TO GENERATE MULTIVIRAL CTLS WITH BROAD SPECIFICITY
Application
US20260092256A1
Kind: A1
Apr 02, 2026
Assignee
Baylor College of Medicine
Inventors
Ann Marie Leen, Juan Fernando Vera Valdes, Cliona M. Rooney, Ulrike Gerdemann
Abstract
The present invention concerns methods of generating CTLs that are able to target at least one antigen from two or more viruses. The method includes exposing mixtures of peptides for different antigens to the same plurality of PBMCs and, at least in certain aspects, expanding the cells in the presence of IL4 and IL7.
CPC Classifications
C12N 5/0638
A61K 39/12
A61K 40/11
A61K 40/46
C07K 14/025
C07K 14/03
C07K 14/11
C07K 14/135
C12N 7/00
A61K 2039/55527
A61K 2039/57
A61K 2039/572
A61K 2039/577
A61K 2039/70
C12N 2501/2302
C12N 2501/2304
C12N 2501/2307
C12N 2501/2315
C12N 2710/16134
C12N 2710/16234
Y02A 50/30
Filing Date
2025-01-14
Application No.
19020866