COMPOSITIONS AND METHODS COMPRISING ANTI-NRP2 ANTIBODIES
Application
US20260092122A1
Kind: A1
Apr 02, 2026
Inventors
Luke BURMAN, Yeeting CHONG, Leslie Ann GREENE, David KING, Zhiwen XU, Ryan Andrew ADAMS
Abstract
Provided are affinity matured and humanized antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
CPC Classifications
C07K 16/2863
A61K 39/3955
A61P 35/04
A61K 39/001103
A61K 2039/505
C07K 2317/24
C07K 2317/33
C07K 2317/52
Filing Date
2025-08-07
Application No.
19293892