MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME
Application
US20260092097A1
Kind: A1
Apr 02, 2026
Inventors
Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
Abstract
The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor α/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
CPC Classifications
C07K 14/7155
A61K 38/1793
A61K 38/2086
A61K 39/3955
A61K 45/06
C07K 14/5443
C07K 16/18
C07K 16/2887
C12N 15/09
C12N 15/62
C12P 21/00
A61K 38/00
C07K 2317/622
C07K 2317/732
C07K 2319/00
C07K 2319/21
C07K 2319/22
C07K 2319/30
Filing Date
2025-06-25
Application No.
19248938