ENGINEERED CYTOKINES AND USES THEREOF
Inventors
Louie HENDERSON, Oliver DUTTON, Falk HOFFMANN, Sandro BOTTARO, Istvan REDL, Angela Rita ELIA, Carlo FISICARO, Benjamin OWENS, Patrick KUNZ, Matthew LAKINS, Patrik FOERCH, David LOWE, Kamil TAMIOLA
Abstract
Disclosed herein are engineered cytokines, compositions and uses thereof, and in silico methods for engineering cytokines generated from artificial neural network machine learning protocols and/or molecular dynamics simulations. Also disclosed herein are poly peptide structures designed using AI methods with modulated stability, potency and developability. Also disclosed herein are compositions containing engineered cytokine for pharmaceutical use, as well as methods of treating a subject by administering to the subject compositions containing the same.
CPC Classifications
Filing Date
2024-05-03
Application No.
19481848