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ENGINEERED CYTOKINES AND USES THEREOF

Application US20260092094A1 Kind: A1 Apr 02, 2026

Inventors

Louie HENDERSON, Oliver DUTTON, Falk HOFFMANN, Sandro BOTTARO, Istvan REDL, Angela Rita ELIA, Carlo FISICARO, Benjamin OWENS, Patrick KUNZ, Matthew LAKINS, Patrik FOERCH, David LOWE, Kamil TAMIOLA

Abstract

Disclosed herein are engineered cytokines, compositions and uses thereof, and in silico methods for engineering cytokines generated from artificial neural network machine learning protocols and/or molecular dynamics simulations. Also disclosed herein are poly peptide structures designed using AI methods with modulated stability, potency and developability. Also disclosed herein are compositions containing engineered cytokine for pharmaceutical use, as well as methods of treating a subject by administering to the subject compositions containing the same.

CPC Classifications

C07K 14/54

Filing Date

2024-05-03

Application No.

19481848