PRODUCTION OF NERVE GROWTH FACTOR (NGF) AND OF MUTEINS THEREOF
Application
US20260092090A1
Kind: A1
Apr 02, 2026
Assignee
Chiesi Farmaceutici SpA
Inventors
Bruno Pietro Imbimbo
Abstract
The present invention relates to a process for production of nerve growth factor (NGF) and muteins thereof, in particular muteins of human NGF. The process of the present invention yields nerve growth factor (NGF) and muteins thereof, e.g. from recombinant sources, at high purity. Aspects related to the process of the present invention, such as muteins obtainable thereby, are also described. The respective muteins may be characterized e.g. by improved detectability and/or reduced nociceptive activity, compared to wildtype human NGF.
CPC Classifications
C07K 14/48
C07K 1/165
C12N 9/6427
A61K 38/00
Filing Date
2025-07-10
Application No.
19265384