PRODUCTS AND METHODS FOR USE IN TREATING NDP-RELATED DISEASES
Application
US20260091131A1
Kind: A1
Apr 02, 2026
Inventors
Jane SOWDEN, Valda PAUZUOLYTE, James WAWRZYNSKI, Aara PATEL
Abstract
The invention relates to a construct and AAV particle comprising a wildtype NDP nucleic acid sequence or a codon-optimised NDP nucleic acid sequence. The invention further relates to products and methods for the treatment of one or more of Norrie disease, age related hearing loss, diabetic maculopathy and retinopathy, retinal neovascularisation, retinal exudation, retinopathy of prematurity (ROP), Familial exudative vitreoretinopathy (FEVR), Coats disease, and other NDP-related diseases, or other beta catenin signalling-related retinal diseases.
CPC Classifications
A61K 48/005
A61K 9/0019
A61K 9/0048
A61K 48/0075
A61K 48/0083
A61P 27/12
A61P 27/16
C07K 14/475
C12N 15/86
A61K 38/00
C12N 2750/14143
C12N 2750/14145
C12N 2800/22
Filing Date
2023-10-10
Application No.
19120184