AMINO ACID-MODIFIED LIPIDS FOR RNA DELIVERY
Application
US20260091126A1
Kind: A1
Apr 02, 2026
Inventors
Kun CHENG, Pratikkumar Vinodchandra PATEL
Abstract
Described herein is the preparation and use of amino acid-modified lipids for delivery of a small interfering RNA (siRNA), mRNA, miRNA, shRNA, or oligonucleotide via formation of lipid nanoparticles (LNPs) comprising the siRNA, mRNA, miRNA, shRNA, or oligonucleotide and the amino acid-modified lipid. Use of the described lipid nanoparticles to silence overexpression of oncogenes is described.
CPC Classifications
A61K 47/6929
A61K 47/542
A61K 47/6455
C07K 5/06086
C07K 5/06147
C07K 5/0815
C07K 5/0821
C07K 5/1019
C07K 5/1024
C12N 15/88
Filing Date
2023-09-19
Application No.
19113514