COMBINATION OF ANTI-B7-H3 ANTIBODY-DRUG CONJUGATE AND ATR INHIBITOR OR ATM INHIBITOR

Abstract

In some aspects, an object of the present invention is to provide a pharmaceutical composition and a method of treatment comprising administering a specific anti-B7-H3 antibody-drug conjugate in combination with an ATR inhibitor or an ATM inhibitor. Solution: In some aspects, provided is a pharmaceutical composition and a method of treatment, comprising administering an antibody-drug conjugate, in which a drug-linker represented by the following formula: wherein A represents a connecting position to an anti-B7-H3 antibody, and the anti-B7-H3 antibody are conjugated via a thioether bond, in combination with an ATR inhibitor or an ATM inhibitor.

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