CELL-PENETRATING PEPTIDES
Application
US20260091120A1
Kind: A1
Apr 02, 2026
Inventors
Matthew WOOD, Samir EL ANDALOUSSI, Graham MCCLOREY, Raquel MANZANO, Michael J. GAIT, Caroline GODFREY, Andrey ARZUMANOV, Liz O'DONOVAN, Richard RAZ
Abstract
The present invention relates to peptides, in particular cell-penetrating peptides, having a first hydrophobic domain positioned at the C-terminus of the peptide and a second hydrophobic domain positioned at the N-terminus of the peptide, and to conjugates of such cell-penetrating peptides with a therapeutic molecule. The present invention further relates to use of such peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders and in particular muscular dystrophies such as Duchenne muscular dystrophy.
CPC Classifications
A61K 47/645
C07K 7/08
C07K 14/00
C12N 15/113
C07K 2319/10
C12N 2310/11
C12N 2310/3513
C12N 2320/32
Filing Date
2025-10-21
Application No.
19363869