CHIMERIC ANTIGEN RECEPTORS BINDING NECTIN-4
Application
US20260091114A1
Kind: A1
Apr 02, 2026
Assignee
Fred Hutchinson Cancer Center
Inventors
John K. Lee, Li-Ting Wu
Abstract
Chimeric antigen receptors (CAR) with a binding domain that binds Nectin-4 are disclosed. The Nectin-4 binding domain can be derived from the murine antibody M22-321b41.1. The CAR disclosed herein can be expressed by an immune cell to be used in the treatment of Nectin-4-expressing cancers, such as bladder, breast, ovarian, esophageal, lung, colorectal, or pancreatic cancers.
CPC Classifications
A61K 40/4202
A61K 40/11
A61K 40/31
C07K 14/7051
C07K 16/2803
C07K 2317/622
Filing Date
2023-09-14
Application No.
19112145