TRANSCRIPTIONAL AND TRANSLATIONAL DUAL REGULATED ONCOLYTIC HERPES SIMPLEX VIRUS VECTORS
Application
US20260091069A1
Kind: A1
Apr 02, 2026
Inventors
William Wei-Guo Jia, Dmitry V. Chouljenko, I-Fang Lee, Yanal M. Murad, Xiaohu Liu, Guoyu Liu, Xuexian Bu, Zahid Delwar, Jun Ding
Abstract
A herpes virus vector is provided with both transcriptional and translational control. Within various embodiments the herpes virus vector is based upon a modified herpes virus and has both ICP27 and ICP34.5 under control of a CEA promoter and miRNA-124/143, respectively, and deletion of at least one copy of terminal repeat long region is provided to increase safety without sacrificing efficacy. The herpes virus vector can also incorporate a virus-expressed cytokine cassette encoding IL-12, IL-15/IL-15RA under the control of CXCR4 promoter.
CPC Classifications
A61K 35/763
A61K 38/208
A61K 38/2086
A61P 35/00
C12N 7/00
C12N 2710/16032
C12N 2710/16071
Filing Date
2022-03-24
Application No.
18283654