ANTIBODY AND CHIMERIC ANTIGEN RECEPTORS TARGETING GCC AND METHODS OF USE THEREOF
Application
US20260091061A1
Kind: A1
Apr 02, 2026
Inventors
Xiaohu FAN, Panglian XU, Qiuchuan ZHUANG, Min WEI, Jiangjing TANG, Chenchen ZHENG, Xu FANG
Abstract
Provided are anti-GCC single domain antibodies (e.g., VHH domain antibodies), and chimeric antigen receptors (CARs) that bind to GCC comprising same in an extracellular antigen binding domain, a transmembrane domain, and an intracellular signaling domain. Immune cells transduced with the disclosed CAR constructs and/or a chimeric receptor can be used for cancer immunotherapy.
CPC Classifications
A61K 35/17
A61K 40/11
A61K 40/31
A61K 40/4244
A61P 35/00
C07K 14/7051
C07K 14/70517
C07K 14/70578
C07K 16/40
C12N 15/85
A61K 2239/13
A61K 2239/17
A61K 2239/21
A61K 2239/22
A61K 2239/29
A61K 2239/50
C07K 2317/22
C07K 2317/24
C07K 2317/565
C07K 2317/567
C07K 2317/569
C07K 2319/00
Filing Date
2023-09-28
Application No.
19111667