PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE
Application
US20260091024A1
Kind: A1
Apr 02, 2026
Inventors
Jay Edward Wrobel, Allen B. Reitz, Jeffrey Claude Pelletier, Garry Robert Smith, Haiyan Bian
Abstract
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
CPC Classifications
A61K 31/428
A61K 9/006
A61K 9/1617
A61K 9/2004
A61K 31/454
A61K 31/496
A61K 31/5377
A61K 38/05
A61K 38/06
A61K 45/06
A61P 25/00
A61P 25/28
C07D 277/82
C07D 417/12
C07K 5/06026
C07K 5/0806
C07K 5/0808
C07K 5/0812
A61K 9/0056
A61K 9/2018
A61K 9/2063
A61K 9/485
A61K 9/4858
A61K 9/4866
A61K 2300/00
Filing Date
2025-02-27
Application No.
19064963