TRANSGENIC NON-HUMAN ANIMALS PRODUCING MODIFIED HEAVY CHAIN-ONLY ANTIBODIES
Application
US20260090529A1
Kind: A1
Apr 02, 2026
Inventors
Wim van Schooten, Nathan Trinklein, Shelley Force Aldred, Marianne Bruggemann, Mike Osborn
Abstract
Human or chimeric heavy chain-only antibodies are provided, in the native amino acid residue at the first position of the fourth framework region (FR4) of said HCAb is substituted by a different amino acid residue that is capable of disrupting a surface-exposed hydrophobic patch comprising or associated with the native amino acid residue at that position.
CPC Classifications
A01K 67/0275
A01K 67/027
C07K 16/00
A01K 2217/052
A01K 2227/105
A01K 2267/01
C07K 2317/21
C07K 2317/24
C07K 2317/52
C07K 2317/522
C07K 2317/565
C07K 2317/567
C07K 2317/569
C12N 15/902
Filing Date
2025-11-18
Application No.
19393163