PRODUCTION AND APPLICATIONS OF OVARIAN AND UTERINE ORGANOIDS

Abstract

Featured are compositions, methods, and apparatuses for biosynthetic organs, or organoids, that replicate tissues of the human female reproductive system (e.g., ovarian or uterine tissues). In particular, the disclosure features methods of culturing or 2024/054644 producing organoids or uteroids from pluripotent stem or progenitor cells and using the resulting organoids or uteroids to screen for safe and effective pharmaceutical interventions for diseases of interest. Such methods and compositions are particularly useful for the treatment of patients undergoing hormone replacement therapy (HRT) and/or assisted reproduction technology (ART) procedures, such as in vitro fertilization and in vitro oocyte maturation. WO

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