GALNAC MONOMER COMPRISING RIBOSE RING OR DERIVATIVE STRUCTURE THEREOF AND USE THEREOF IN LIVER-TARGETED DELIVERY OF SMALL NUCLEIC ACID DRUGS
Application
US20260085320A1
Kind: A1
Mar 26, 2026
Inventors
Zeao Huang, Gengshen Song, Zhikang Tian, Shuo Yang, Yucheng Wu, Rui Fu
Abstract
The present disclosure provides a GalNAc monomer comprising a ribose ring or a derivative structure thereof and a use thereof in liver-targeted delivery of small nucleic acid drugs. Specifically provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof. The GalNAc-conjugated oligonucleotide prepared from the GalNAc compound provided by the present disclosure can achieve efficient liver-targeted delivery and enhance drug efficacy.
CPC Classifications
C12N 15/1137
A61P 9/12
C12N 15/1131
C12N 2310/11
C12N 2310/14
C12N 2310/315
C12N 2310/351
C12N 2320/32
C12Y 304/21027
C12Y 304/21061
Filing Date
2025-09-22
Application No.
19336466