SIRNA FOR TARGETED INHIBITION OF AGT GENE EXPRESSION AND USE THEREOF IN TREATING HYPERTENSION
Application
US20260085317A1
Kind: A1
Mar 26, 2026
Inventors
Gengshen Song, Zeao Huang, Shuo Yang, Guangshen Ji, Zhikang Tian, Yucheng Wu, Zhongcai Gao, Wei Zhang, Man Zhang
Abstract
The present disclosure provides a modified oligonucleotide sequence and use thereof. A series of siRNAs were designed based on the angiotensinogen (AGT) messenger ribonucleic acid (mRNA) sequence, which were alternately modified or modified using a specific set of modification templates. The results from cell and animal experiments demonstrated that some oligonucleotide sequences with alternating modifications and specific template modifications can significantly inhibit AGT gene expression and may be used for the development of medicaments for treating hypertension and other related diseases.
CPC Classifications
C12N 15/113
A61K 31/7115
A61K 31/712
A61K 31/7125
A61K 31/713
A61P 9/12
C12N 2310/11
C12N 2310/14
C12N 2310/3125
C12N 2310/315
C12N 2310/321
C12N 2310/322
C12N 2310/335
C12N 2310/336
C12N 2310/351
Filing Date
2025-09-26
Application No.
19341325